Binder

ABSTRACT Introduction Increasing attention is being afforded to understanding the bidirectional relationships that exist between oral medications and the gut microbiota, in an attempt to optimize pharmacokinetic performance and mitigate unwanted side effects. While a wealth of research has…
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Pharma Solutions at IFF provides you access to one of the broadest microcrystalline cellulose (MCC) portfolios in the industry. Backed by decades of innovation, and expertise, Avicel® PH offers a long history of manufacturing the highest-quality pharmaceutical grade MCC. Our deep polymer…
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With the emergence of quality by design (QbD), it becomes imperative to gain understanding of the impact of batch-to-batch variability of raw materials on the performance of processes. Feeding is the first unit of operation in a continuous manufacturing line and is critical for the final product…
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Food compacts are convenient to industry and customers and must primarily possess a sufficient strength to withstand packaging processing and customer handling. In contrast to pharmaceutical applications, the choice of excipients is usually limited to necessary ingredients of the final food product.…
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Vitamin C (ascorbic acid) is a popular supplement available over the counter in dosage forms such as tablets, capsules, sprinkles and gummies. From a formulator’s perspective, it can be challenging since it is poorly compressible and is very sensitive to moisture. Because of this, it requires…
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In the last decades, continuous manufacturing (CM) has become a research priority in the pharmaceutical industry. However, significantly fewer scientific researches address the investigation of integrated, continuous systems, a field that needs further exploration to facilitate the implementation of…
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Abstract For the continuous operation of granulation, which is a standard unit operation in powder processing to modify the particle size, the use of twin-screw machines was established as standard method for wet and melt granulation over the last decade. A main characteristic for this technology…
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摘要益生菌微生物提供医疗benefits to the patient when administered in a viable form and in sufficient doses. To ensure this, dry dosage forms are preferred, with tablets in particular being favored due to several advantages. However, the microorganisms must first be dried as…
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Phage therapy is recognized to be a promising alternative to fight antibiotic-resistant infections. In the quest for oral dosage forms containing bacteriophages, the utilization of colonic-release Eudragit® derivatives has shown potential in shielding bacteriophages from the challenges encountered…
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ABSTRACT Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood. Here, we aimed to elucidate the…
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