A wide variety of pharmaceutical products, including pellets, granules, capsules, powders, and crystals are often coated. The procedure ofcoatingtablets is a complex process that results in the forming of a thin layer around the tablet. This layer is in the range of 20 to 200 μm in thickness, or around 1 to 9% of the initial weight of the tablet.
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Coating
Formulation development with Kollicoat Smartseal: Impact of plasticizers
How can plasticizers impact the functionality of film-coating latex-based dispersion? When formulating a film coating, plasticizers are often required to increase polymer chain mobility, improve mechanical properties, such as elasticity and cracking resistance, and reduce the minimum film…
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Enteric-Coated Cysteamine Bitartrate in Cystinosis Patients
Cystinosis is a severe inherited metabolic storage disease caused by the lysosomal accumulation of cystine. Lifelong therapy with the drug cysteamine bitartrate is necessary. Cysteamine cleaves intralysosomal cystine, and thereafter, it can exit from the organelle. The need for frequent dosing every…
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Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines
Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms…
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Understanding the correlations between tablet flow dynamics and coating uniformity in a pan coater:…
Coating uniformity is crucial for pharmaceutical solid dosages to ensure sufficient stability and to program drug release behavior. The present study aims to thoroughly investigate the correlation between the coating uniformity and the tablet flow dynamics with a novel computational model. The model…
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Kollicoat® Smartseal combines an effective taste-masking functionality with efficient processing
Kollicoat® Smartseal 30 D and Kollicoat® Smartseal 100 P can help formulators tackle challenges when handling bitter active ingredients. It offers superior protection from unpleasant drug taste for minitablets, pellets, particles, and granules used in orally disintegrating dosage forms, improving…
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Enteric coating of tablets containing an amorphous solid dispersion of an enteric polymer and a…
Recent work has highlighted that amorphous solid dispersions (ASDs) containing delamanid (DLM) and an enteric polymer, hypromellose phthalate (HPMCP), appear to be susceptible to crystallization during immersion in simulated gastric fluids. The goal of this study was to minimize contact of the ASD…
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MCC Spheres Facilitate Precise Dissolution Profile of Controlled Release Formulations
A 100% MCC sphere, Celphere™ has high sphericity and narrow particle size distribution. Also, Celphere™ is less damaged during film coating process because of its high mechanical strength. With regard to comparison with sugar spheres, Celphere™ can prevent agglomeration during film coating process…
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A validation of discrete-element model simulations for predicting tablet coating variability
Abstract Achieving an even coating distribution on tablets during the coating process can be challenging, not to mention the challenges of accurately measuring and quantifying inter-tablet coating variability. Computer simulations using the Discrete Element Method (DEM) provide a viable pathway…
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Solid implantable devices for sustained drug delivery
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes. Oral and injectable drug administration are the most common routes for drug delivery providing peaks of drug concentrations in blood after administration followed by concentration decay…
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Polyvinyl alcohol: Revival of a long lost polymer
介绍了面向目标的药物发现nd an increasing focus on specialized medicines, the manufacturing of final drug products is becoming more and more complex. The processing and formulation of active pharmaceutical ingredients (APIs) designed with a specific target and functionality…
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