Gattefossé – Lipid Excipients
Gattefossé is a leading provider of lipid excipients and formulation solutions to healthcare industries worldwide. We are committed to delivering high quality excipients, technical support and inspiring your formulations. With an in-depth knowledge of lipid excipient physicochemical and functional properties, we are your reliable partner for drug development.
For almost 140 years, successive generations of scientists have been contributing to the development of Gattefossé’s know-how in plant extraction and lipochemistry. This expertise has extended throughout the years to other complementary fields with the aim to develop, produce and market first-class products and services of a consistently high quality, while leading the way for innovation and creativity.
12 sales affiliates and more than 60 distributors worldwide,
excellent local technical and sales support,
4 application laboratories—in France, China, India, and the US—for formulation troubleshooting, special product developments, or exclusive prototypes,
- attentive and responsive customer service and personalized follow-up
Lipid-based nanocarriers are promising tools to deliver APIs, including peptides, as their nanosize are in favour of transepithelial transport.
Solid Lipid Nanoparticles (SLN)是由脂质在固态房间吗body temperature, usually long chain triglycerides or partial glyceride, fatty acids, waxes, etc.
Precirol®ATO 5 is the preferred solid lipid carrier as it is digestible and exhibits a low melting point (around 50-55°C).
Nanostructured Lipid Carriers (NLC)contain both solid and liquid lipid at room and body temperature. The liquid lipids act as crystallization inhibitors of the solid lipid.
Capryol®90 is the preferred liquid lipid excipient.
一个简短的介绍Maisine®CC,新的制药aceutical oil from Gattefossé, a solubility and oral bioavailability enhancer! Maisine® CC is Gattefossé’s tradename for Glycerol/Glyceryl monolinoleate (EP, USP-NF), also known as corn oil mono-, di-, and triglycerides and corn glycerides (FDA IID).
This unique pharmaceutical oil has a long and successful history of use in lipid-based formulation (LBF) for oral bioavailability enhancement. In LBF Maisine® is associated with drug solubilization and increased oral bioavailability and in certain cases mitigation of food effect and lymphatic drug absorption – thereby reducing first-pass metabolism.
Oral drug delivery
Functional lipid excipients are designed to meet the most pressing formulation challenges in drug development:
Poor solubility, permeability and bioavailability, with lipid-based drug delivery systems consisting of single or multiple excipients, forming oily formulations, self-emulsifying (SEDDS) and self-microemulsifying (SMEDDS) formulations or micellar solutions. Examples:Labrasol® ALFandLabrasol®
Modified or sustained-release lipid matrices that are water-insoluble and do not swell or erode when in contact with aqueous media. They form an inert matrix from which the drug diffuses slowly over time.
Protection of sensitive API and taste-masking when used in melt processes, due to the formation of a filmcoatingaround the drug particle.
Topical drug delivery
Functional lipid excipients are used to formulate creams, lotions, ointments, oily and aqueous gels and foams.
Improved texture and sensorial properties positively impact patient experience and adherence to treatment. Optimizing stability, texture and sensorial qualities of a topical product can be achieved with the selection of the right combination of emulsifiers and consistency agents.
Rectal and vaginal drug delivery
Functional lipid excipients are used to formulate suppositories, pessaries, creams, ointments and foams.