DC Excipients – A list of excipients for direct compression

Direct compression (DC) the fastest and most economic way to manufacture a tablet as it directly goes from powder mixing to tableting without any further production steps. It plays a key role in continuous manufacturing thanks to the high efficiency and the very small footprint in production. The excipients in use such as binders, lubricants and disintegrants are key elements for a successful DC process. Therefore specific excipients or special types of excipients have been developed to fulfill the needs of direct compression.

pharmaexcipients has put together a list of excipients for direct compression (DC excipients) incl. function and manufacturer. Pleaseget in touchwith us for any update or missing excipient we will gladly add it as soon as possible.

Commercial Name Composition Function / Application Manufacturer
A-TAB Anhydrous dibasic calcium phosphate Filler, Binder Innophos
AceCelTM 12 Microcrystalline Cellulose Filler, Binder Sigachi
AceCelTM 102 Microcrystalline Cellulose Filler, Binder Sigachi
AceCelTM 112 Microcrystalline Cellulose Filler, Binder Sigachi
AceCelTM 200 Microcrystalline Cellulose Filler, Binder Sigachi
AceCelTM 302 Microcrystalline Cellulose Filler, Binder Sigachi
Advantose 100 Maltose Filler, Binder SPI Pharma
Advantose FS 95 Fructose, starch Chewable tablets SPI Pharma
Anhydrous DT Anhydrous Lactose Kerry
Anhydrous DT HV Sieved Anhydrous Lactose DT Kerry
ARBOCEL A 300 Powdered Cellulose Filler JRS Pharma
Avicel CE-15 Microcrystalline Cellulose, guar gum Improve mouthfeel for chewable tablets DuPont
Avicel PH 102 Microcrystalline Cellulose Filler, Binder DuPont
Avicel PH 200 Microcrystalline Cellulose Filler, Binder DuPont
Avicel PH 200 LM Microcrystalline Cellulose Filler, Binder DuPont
Barcroft CS 90 Calcium Carbonate, starch SPI Pharma
Barcroft Premix St SPI Pharma
Barcroft USP 321 Aluminium Hydroxide SPI Pharma
Benecel K4M DC Hydroxylpropylmethylcellulose, HPMC Controlled release matrix polymer Ashland Specialty Ingredients
Benecel K15M DC Hydroxylpropylmethylcellulose, HPMC Controlled release matrix polymer Ashland Specialty Ingredients
Benecel K100M DC Hydroxylpropylmethylcellulose, HPMC Controlled release matrix polymer Ashland Specialty Ingredients
BonuCel® D 3 H 2910 Hydroxylpropylmethylcellulose, HPMC Filler, Binder BIOGRUND
BonuCel® D 6 H 2910 Hydroxylpropylmethylcellulose, HPMC Filler, Binder BIOGRUND
BonuTab® Fillers, binders, lubricants, pigments and dyes All-in-one excipient BIOGRUND
CALCI-PRESS™ 90 S Calcium carbonate Seppic
Captisol Modified cyclodextrin Cydex, Lenexa, KS
Carbofarma GA10 Calcium Carbonate, Acacia Resina Industriales SA.
Carbofarma GM11 Calcium Carbonate, Maltodextrin Resina Industriales SA.
Carbopol 71G NF Carbomer Homopolymer Type A Lubrizol
Cellactose 80 Cellulose, lactose Meggle
Celocal Microcrystalline Cellulose, calcium phosphate DuPont
CombiLac Lactose & Microcrystalline Cellulose Meggle
CompactCel® Hydroxylpropylcellulose/NaCMC or PVP/NaCMC Binder, direct compression BIOGRUND
CompactCel® LUB Hydroxylpropylcellulose or MCC, oil/wax, vegetable rice extract Binder, Lubricant,
direct compression
BIOGRUND
CompactCel® MAB Silicondioxide, Calciumcarbonate, MCC and/or Talc Binder, direct compression BIOGRUND
CompactCel® SIL Silicondioxide + Hydroxylpropylcellulose/NaCMC or PVP/NaCMC Binder, direct compression BIOGRUND
CompactCel® TC Sweetners, polymers, beta-cyclodextrin, cellulose Binder, direct compression BIOGRUND
COMPACTROL Calcium Sulfate Filler JRS Pharma
Compritol® 888 ATO Glyceryl dibehenate Lubricant challenging pharmaceutical tablets Gattefossé
Compritol® E ATO Glyceryl dibehenate Lucricant for challenging nutraceutical tablets Gattefossé
Compritol® HD 5 Glyceryl dibehenate Lucricant for water-dispersible tablets Gattefossé
Delaflo Calcium sulphate Delaflo
Di-Cafos anhydrous dibasic calcium phosphate Budenheim
DI-CAFOS® A 150 dicalcium phosphate anhydrous Filler / diluent Budenheim
DI-CAFOS® A 60 dicalcium phosphate anhydrous Filler / diluent Budenheim
DI-CAFOS® D 160 dicalcium phosphate dihydrate Filler / diluent Budenheim
Di-Pac Sucrose, dextrin American Sugar
DirectTab N 微晶纤维素,磷酸三钙nd Guar Gum Readymix for Neutraceutrical applications Sigachi
DirectTab ODT Microcrystalline Cellulose, Mannitol, Silicon Dioxide, Croscarmellose Sodium ODT Sigachi
DirectTab P Microcrystalline Cellulose, Silicon Dioxide, Talc, Croscarmellose Sodium Readymix for Direct compression Sigachi
Disintequik Granule of Spray dried lactose and croscarmellose sodium Kerry
Disintequik MCC 10 Granule of Spray dried lactose 90% MCC10% Kerry
Disintequik MCC 25 Granule of Spray dried lactose 75% MCC25% Kerry
Disintequik ODT Granule of: Lactose Monohydrate, NF/EP/JP
Mannitol, USP
Crospovidone, NF
Dextrose Monohydrate, NF
Oral disintegrating tablet mix Kerry
DuraLac H Lactose, anyhdrous Meggle
EMCOCEL 90 M Microcrystalline Cellulose Filler, Binder JRS Pharma
EMCOCEL 90 M coarse Microcrystalline Cellulose Filler, Binder JRS Pharma
EMCOCEL HD 90 Microcrystalline Cellulose Filler, Binder JRS Pharma
EMCOCEL LP 200 Microcrystalline Cellulose Filler, Binder JRS Pharma
EMCOCEL XLM 90 Microcrystalline Cellulose Filler, Binder JRS Pharma
EMCOMPRESS Dibasic Calcium Phosphate, Dihydrate Filler JRS Pharma
EMCOMPRESS anhydrous Dibasic Calcium Phosphate, anhydrous Filler JRS Pharma
EMCOMPRESS Premium Dibasic Calcium Phosphate, Dihydrate Filler JRS Pharma
EMDEX Dextrates, NF Filler-Binder JRS Pharma
EraTab Starch National Starch
Eudragit RL and RS Methacrylica acid polymers Evonik
EXCIPRESS™GR150 Lactose, granulated Filler, Binder Armor Pharma
EXCIPRESS™SD2 Lactose, spray-dried Filler, Binder Armor Pharma
Fast flo 315,316 Spray dried lactose Direct compression where Great Flow is needed Kerry
Finlac DC Lactitol Danisco
FlowLac (90, 100) Lactose, spray-dried Meggle
Fujicalin anhydrous dibasic calcium phosphate Fuji Chemicals
galenIQ 721 Isomalt High soluble filler-binder for fast disintegration with great taste profile BENEO-Palatinit
galenIQ™ 720 Isomalt Direct compressible filler-binder with great taste profile BENEO-Palatinit
Gohsenol EG-03 P, EG-05 P Polyvinylalcohol Binder Nippon Gohsei Co., Ltd.
GRANFILLER-D Mannitol, Microcrystalline Cellulose, Carmellose and Crospovidone Readymix for Direct compression DAICEL
HarkePlus Tab Microcrystalline Cellulose/HPC/Ca phosphate Binder Harke Pharma
Health in Gum, Types HiG PWD 01, HiG PWD 03, HiG PWD 04 30% Gum base, Sorbitol, Xylitol, Mannitol Chewing Gum base Cafosa Gum S.A.U.
HiCelTM 12 Microcrystalline Cellulose Filler, Binder Sigachi
HiCelTM 90M Microcrystalline Cellulose Filler, Binder Sigachi
HiCelTM CE15 Microcrystalline Cellulose & Guar Gum Improve mouth feel of chewable tablets Sigachi
HiCelTM HD 90 Microcrystalline Cellulose Filler, Binder Sigachi
HiCelTM HFE 50M Microcrystalline Cellulose & Mannitol Filler, Binder Sigachi
HiCelTM HFE 90M Microcrystalline Cellulose & Mannitol Filler, Binder Sigachi
HiCelTM LP200 Microcrystalline Cellulose Filler, Binder Sigachi
HiCelTM SMCC 50M Microcrystalline Cellulose & Colloidal Silicon Dioxide Filler, Binder Sigachi
HiCelTM SMCC 90M Microcrystalline Cellulose & Colloidal Silicon Dioxide Filler, Binder Sigachi
HiCelTM SMCC HD90 Microcrystalline Cellulose & Colloidal Silicon Dioxide Filler, Binder Sigachi
HiCelTM SMCC LM90 Microcrystalline Cellulose & Colloidal Silicon Dioxide Filler, Binder Sigachi
HiCelTM XLM 90 Microcrystalline Cellulose Filler, Binder Sigachi
HiCelTM XLM 200 Microcrystalline Cellulose Filler, Binder Sigachi
HiSORAD Mannitol, Microcrystalline Cellulose and Croscarmellose sodium Readymix for Direct compression DAICEL
Klucel EXF HPC Hydroxypropyl cellulose Binder Ashland Specialty Ingredients
Klucel Nutra D HPC Hydroxypropyl cellulose Binder Ashland Specialty Ingredients
Kollidon Cl, CL-F, CL-SF, CL-M Crosslinked water-soluble PVP BASF
L-HPC: LH 21, L-HPC LH B1, L-HPC NBD-021 Hydroxypropylcellulose ( HPC), low substituted Binder with disintegration properties Shin Etsu Chemial Co., Ltd.
Lubritose AN Granule of Anhydrous Lactose with GMS Co-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Lubritose Colour Potential to add colour to excipient (lactose, MCC or Mannitol) Co-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Lubritose Mannitol Spray dried Mannitol with GMS Co-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Lubritose MCC Granule MCC with GMS Co-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Lubritose Placebo 喷雾干燥的乳糖,世纪挑战集团和通用汽车S Co-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Lubtitose SD Granule of Spray-dried lactose with GMS Co-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Ludiflash Mannitol, PVA, crospovidone Direct compression ODT BASF
Magnipress 90 Magnesium carbonate Seppic
Maltrin Maltodextrin GPC
Mannogem 2080 Mannitol SPI Pharma
Methocel DC2 HPMC DuPont
MicroceLac Microcrystalline Cellulose, Lactose Meggle
Neosorb 60 Sorbitol Roquette
Nisso HPC SSL-SFP Hydroxypropyl cellulose Highest efficiency Direct Compression binder. SSL means “Super Super Low” molecular weight for minimal impact on disintegration and dissolution. SFP means micronized “Super Fine Powder” for high specific surface area to maximize binding efficiency. Binding efficiency is 2-3x greater than traditional HPC/HPMC and 5x MCC. Nisso America
Nu-Tab sucrose, invert sugar, cornstarch and magnesium stearate Colorcon
PanExaea MCC333G Microcrystalline Cellulose, HPMC, PVP Mallinckrodt Baker
PARTECK® CCS Croscarmellose Sodium For use as Super disintegrant with superior disintegration performance Merck KGa
Parteck® LUB CST Calcium stearate 用作滑ricant with reliable performance through specified PSD and BET Merck KGa
Parteck® LUB MST Magnesium stearate 用作滑ricant with reliable performance through specified PSD and BET Merck KGa
Parteck® LUB STA 50 Stearic acid 用作滑ricant with reliable performance through specified PSD and BET Merck KGa
Parteck® M 100 Mannitol Direct compressible Mannitol with excellent binding properties and low content in reducing sugars for use as filler/binder Merck KGa
Parteck® M 200 Mannitol Direct compressible Mannitol with excellent binding properties and low content in reducing sugars for use as filler/binder Merck KGa
Parteck® Mg DC Magnesium hydroxide carbonate Direct compressible inorganic filler/binder with large surface area. Also for use as API carrier. Merck KGa
Parteck® ODT Mannitol + Croscarmellose-Na For use as a filler/Binder in formulation of ODT-Tablets with excellent binding and disintegration properties and stability Merck KGa
Parteck® SI 150 Sorbitol Direct compressible Sorbitol with excellent binding properties and outstanding palatability for use as filler/binder Merck KGa
Parteck® SI 200 Sorbitol Direct compressible Sorbitol with excellent binding properties and outstanding palatability for use as filler/binder Merck KGa
Parteck® SI 400 Sorbitol Direct compressible Sorbitol with excellent binding properties and outstanding palatability for use as filler/binder Merck KGa
Parteck® SI 400 LEX Sorbitol Direct compressible Sorbitol with excellent binding properties and outstanding palatability for use as filler/binder. Low in endotoxins. Merck KGa
Parteck® SLC 500 Silicon dioxide Functional inorganic carrier with large specified surface area, for solubility
enhancement of poorly water soluble APIs; API-loaded carrier suitable for direct compression
Merck KGa
Parteck® SRP 80 Polyvinyl alcohol Functional polymer for reliable sustained release matrix formulations in oral solids, with specified medium particle size, suitable für direct compression Merck KGa
Pearlitol Flash Mannitol, maize starch Direct compression ODT Roquette
Pearlitol SC Granulated Mannitol Roquette
Pharm DC 93000 Starch Cerestar
Pharmacoat 603, 606 Hydroxypropylymethylcellulose ( HPMC) Binder Shin Etsu Chemial Co., Ltd.
Pharmatose DCL 40 B-Lactose, lactitol DMV
Plasdone S630 Vinyl acetate, vinyl pyrrodlidone SPI Pharma
Polyplasdone XL corospovidone Disintegrant Ashland Specialty Ingredients
Polyplasdone XL 10 crospovidone Disintegrant Ashland Specialty Ingredients
Primecel 102, 302 Microcrystalline Cellulose Binder, Filler Chemfield Pharmaceuticals Pvt. Ltd.
PROSOLV 90 LM MCC, Colloidal Silicon Dioxide Filler-Binder JRS Pharma
PROSOLV EASYtab Nutra MCC, Colloidal Silicon Dioxide, Croscarmelose Sodium, Hydrogenated Plant Oil, DATEM All-in-one excipient,
nutraceutical version
JRS Pharma
PROSOLV EASYtab SP MCC, Colloidal Silicon Dioxide, Sodium Starch Glycolate, Sodium Stearyl Fumarate All-in-one excipient JRS Pharma
PROSOLV ODT G2 MCC, Colloidal Silicon Dioxide, Mannitol, Fructose, Crospovidone ODT platform JRS Pharma
PROSOLV SMCC 50 MCC, Colloidal Silicon Dioxide Filler-Binder JRS Pharma
PROSOLV SMCC 50 LD MCC, Colloidal Silicon Dioxide Filler-Binder JRS Pharma
PROSOLV SMCC 90 MCC, Colloidal Silicon Dioxide Filler-Binder JRS Pharma
PROSOLV SMCC HD 90 MCC, Colloidal Silicon Dioxide Filler-Binder JRS Pharma
Puracal DC Calcium lactate pentahydrate Purac
Puracal TP Calcium lactate trihydrate Purac
PVP K 25, 30, 90 Polyvinylpyrrolidon Binder Huangshan Bonsun Pharmaceuticals Co., Ltd.
PVPP PVPP-CL, PVPP-XL 10 Cross linked PVP Disintegrant Huangshan Bonsun Pharmaceuticals Co., Ltd.
Ran Explo-C Microcrystalline Cellulose, silica & crospovidone RanQ
跑Explo-S Microcrystalline Cellulose, silica & SSG RanQ
Rediflo AG Agglomerated Lactose Kerry
RetaLac Lactose, Hypromellose Diffusion controlled Dissolution Meggle
RetardCel® Hypromellose, NaCMC Retardation BIOGRUND
SilSol 6035 Silicon Dioxide API carrier with controlled poresize and related high surface area, specially designed for solubility enhancement of BCS2-4; suitable for direct compression Grace
SmartEx QD-50, QD-100 Mannitol, PVA, HPC low substituted ODT Tablets Shin Etsu Chemial Co., Ltd.
Sorbogem Sorbitol SPI Pharma
StarCap 1500 Corn starch, pregelatinized starch Filler, disintegrant Colorcon
StarLac Lactose, starch Filler, disintegrant Meggle
Sucralose powder Sucralose High intensity sweetener. Micronized grade for tableting applications Merck KGa
Surfhope D1803 Stearic acid ester, Palmitic acid ester Lubricant Mitsubishi Kagaku Foods Corporation
Syloid 63FP Silicon Dioxide Moisture scavanger able to stabilise water in a formulation /API protection from chemical degradation due to water activity Grace
Syloid 244F Silicon Dioxide Food grade multifunctional flow improver. While improving flow also taking care of charging, sticking, improving tablet hardness, avoiding physical degradation. Grace
Syloid 244FP Silicon Dioxide Pharma grade multifunctional DC flow improver. While improving flow and uniformity for DC also taking care of charging, sticking, improving tablet hardness, avoiding physical degradation. Stabilising suspension properties. Grace
Syloid AL1FP Silicon Dioxide Moisture scavanger able to stabilise water in a formulation /API protection from chemical degradation due to water activity Grace
Syloid G Silicon Dioxide Flow improvement only Grace
Syloid XDP 3050 Silicon Dioxide Carrier / Tabletting grade for liquisolid technologies Grace
Tablettose (70, 80, 100) Lactose, agglomerated Filler, Binder Meggle
TCC TB Tricalcium citrate tetrahydrate Filler Jungbunzlauer
Tri Tab Tricalcium phosphate Filler Innophos
VIVAPHARM PVP/VA 64 Copovidone Binder JRS Pharma
VIVAPUR 12 Microcrystalline Cellulose Filler, Binder JRS Pharma
VIVAPUR 14VIVAPUR® 14 Microcrystalline Cellulose Filler, Binder JRS Pharma
VIVAPUR 102 Microcrystalline Cellulose Filler, Binder JRS Pharma
VIVAPUR 102 SCG Microcrystalline Cellulose Filler, Binder JRS Pharma
VIVAPUR 112 Microcrystalline Cellulose Filler, Binder JRS Pharma
VIVAPUR 200 Microcrystalline Cellulose Filler, Binder JRS Pharma
VIVAPUR 200 XLM Microcrystalline Cellulose Filler, Binder JRS Pharma
VIVAPUR 302 Microcrystalline Cellulose Filler, Binder JRS Pharma
Xylitab 100 Xylitol, polydextrose Danisco
Kolliphor® P 188, P 407 Micro Micronized Poloxamer Lubricant BASF
Kolliphor® SLS Fine Sodium Lauryl Sulfate Lubricant BASF
Ludipress® Lactose, povidone, crospovidone Three-in-one system for direct compression BASF
Ludipress® LCE Lactose, povidone Ready-to-use direct compression solution for lozenges, chewables and effervescent tablet BASF
Reta M® Mannitol, Hypromellose Sustained release through direct compression Meggle
HiSORAD Mannitol, Microcrystalline Cellulose, and Croscarmellose Sodium Readymix for Direct compression DAICEL
Commercial Name Composition Function / Application Manufacturer
Comprecel M102 Microcrystalline Cellulose Filler/Binder Mingtai Chemical Co., Ltd.
Comprecel M112 Microcrystalline Cellulose Filler/Binder Mingtai Chemical Co., Ltd.
Comprecel M302 Microcrystalline Cellulose Filler/Binder Mingtai Chemical Co., Ltd.
Comprecel M200 Microcrystalline Cellulose Filler/Binder Mingtai Chemical Co., Ltd.
Comprecel M200 LM Microcrystalline Cellulose Filler/Binder Mingtai Chemical Co., Ltd.
Comprecel SMCC 90 Microcrystalline Cellulose Filler/Binder Mingtai Chemical Co., Ltd.
Comprecel SMCC 90 HD Microcrystalline Cellulose Filler/Binder Mingtai Chemical Co., Ltd
Comprecel SMCC 50 Microcrystalline Cellulose Filler/Binder Mingtai Chemical Co., Ltd
Disolcel Croscarmellose Sodium Disintegrant Mingtai Chemical Co.Ltd.
Povidone K25, K30 and K90 Povidone Binder JH Nanhang Life Sciences Co., Ltd
Copovidone VA 64 Polyvinyl Pyrrolidone and Vinyl Acetate Binder JH Nanhang Life Sciences Co., Ltd
Crospovidone XL10 Crospovidone Disintegrant JH Nanhang Life Sciences Co., Ltd
Crospovidone XL Crospovidone Disintegrant JH Nanhang Life Sciences Co., Ltd.
DST Sodium Starch Glycolate Disintegrant Yung Zip Chemical Ind. Co., Ltd.
DICOM SANAQ® LS 004 Lactose, Starch Diluent, Disintegrant Pharmatrans Sanaq AG
DICOM SANAQ® ML 011 Microcrystalline Cellulose, Lactose Binder, Diluent Pharmatrans Sanaq AG
DICOM SANAQ® SP 204 MCC - MgO2 -Starch -
Pregelatizend starch -
Sodium starch glycolate
Dry Binder, Diluent Pharmatrans Sanaq AG
DICOM SANAQ® SP 205 MCC - Colloidal Silicon dioxide -
Povidone K30 -
Crosspovidone
Diluent Pharmatrans Sanaq AG
DICOM SANAQ® SP 206 MCC - Colloidal silicon dioxide -
Polyvinyl pyrrolidone -
Sodium starch glycolate
Diluent Pharmatrans Sanaq AG
DICOM SANAQ® SR 300 Hydroxypropyl Methylcellulose
EC - MCC - HPC - Starch -
Colloidal Silicon dioxide -
Talcum - Mg Stearate
Matrix type of tablets Pharmatrans Sanaq AG
SEPITRAP™ 80 Polysorbate 80 and Magnesium Aluminometasilicate Free flowing powdered dry surfactant for solubility enhancement of insoluble API's. Perfect excipient for direct compression. Seppic
SEPITRAP™ 4000 Polyoxyl 40 hydrogenated castor oil and Magnesium Aluminometasilicate Free flowing powdered dry surfactant for solubility enhancement. Perfect excipient for direct compression. Seppic
SEPISTAB™ ST 200 Partially pregelatinized starch and native starch Unique particle size designed for direct compression. Free flowing powder designed to provide binding and disintegrant properties. Seppic
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