Inorganic Chemicals

的机械强度是一个重要的质量tribute of pharmaceutical tablets. It can be determined using different failure tests like the Brazilian test or the three-point bending test. Nevertheless, literature shows that different failure tests often give conflicting values of tensile…
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目的近期禁止二氧化钛(二氧化钛;E171) for the use in food and nutritional supplements (European Commission). The regulation includes a commitment to review the necessity of titanium dioxide as a white colorant in medicinal products1. It is challenging to find a suitable…
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Particle breakage by attrition is unavoidable in some unit operations and can lead to uncontrolled behavior of materials during processing. The aim of this study is to clarify the impact of material properties on attrition behavior. For the first time, an integral study with varying morphologies and…
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Titanium dioxide is extensively used in solid dosage forms as an opacifier and colorant. Due to regulatory developments and restrictions by authorities, formulators are increasingly interested in titanium dioxide-free solutions for both dietary supplements and medicinal products. Uniform colored and…
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Abstract More challenging active pharmaceutical ingredients are entering the market, spurring the introduction of novel drug delivery strategies that necessitate a paradigm shift from exhausted excipients to materials with combined actions and multiple functionalities. In this study, an inorganic…
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Solid dosage forms based on hypromellose (HPMC) with prolonged/extended drug release are very important from the research and industrial viewpoint. In the present research, the influence of selected excipients on carvedilol release performance from HPMC-based matrix tablets was studied. A…
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As tablets are convenient to administer to patients, ensure safe dosing and allow cost-effective production on a large scale, they are the favored dosage form for numerous active pharmaceutical ingredients but also for the administration of viable probiotic microorganisms. Granules with viable yeast…
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Uniform colored and white coatings applied to tablets create a homogeneous appearance across batches, improving aesthetics and patient compliance. Titanium dioxide is used extensively in solid dosage forms for this purpose, serving as an opacifier and colorant. Due to its high refractive index, it…
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The sticking of active pharmaceutical ingredient (API) to the surfaces of compaction tooling, frequently referred to as punch sticking, causes costly downtime or product failures in commercial tablet manufacturing. Magnesium stearate (MgSt) is a common tablet lubricant known to ameliorate the…
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Abstract Continuous manufacturing is becoming the new technological standard in the pharmaceutical industry. In this work, a twin-screw processor was employed for the continuous production of liquisolid tablets containing either simethicone or a combination of simethicone with loperamide…
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