Sugar Alcohols

The paediatric population has always suffered from a lack of medicines tailored to their needs, especially in terms of accurate dosage, stability and acceptability. Orodispersible dosage forms have gone through a resurrection as an alternative to liquid formulations or fractioned solid formulations,…
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Phage therapy has gained prominence due to the increasing pathogenicity of “super bugs” and the rise of their multidrug resistance to conventional antibiotics. Dry state formulation of therapeutic phage is attractive to improve their “druggability” by increasing their shelf life, improving their…
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The objective of the present investigation was to understand the effect of sucrose acetate isobutyrate (SAIB) on abuse-deterrent properties (ADPs) of abuse-deterrent formulations (ADFs) based on Polyox™. SAIB would enhance ADPs of Polyox™-based formulations due to its glassy liquid and hydrophobic…
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Rapid advancement in drug discovery process is leading to a number of potential new drug candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the submicron particle size and distinct physicochemical properties, nanosuspension has the potential ability to tackle…
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癫痫是一种大脑功能紊乱,影响数百万of people worldwide and is usually managed using currently available antiepileptic drugs, which result in adverse effects and are ineffective in approximately 20-25% of patients. Thus, there is growing interest in the development of new…
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Sucrose is a common cyro- and lyoprotectant to stabilize labile biopharmaceuticals during freeze-drying and storage. Sucrose based formulations require low primary drying temperatures to avoid collapse and monoclonal antibody (mAb) containing products need to be stored refrigerated. The objective…
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Taste is a crucial factor that determines the palatability of the oral dosage form and patient compliance. Objective The aim of this work was to evaluate the organoleptic excipients in oral antibiotics for pediatric use marketed in Brazil. Methods The information was obtained from the…
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Mannitol and lactose are commonly used fillers in pharmaceutical tablets, available in several commercial grades that are produced using different manufacturing processes. These grades significantly differ in particulate and powder properties that impact tablet manufacturability. Choice of…
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Granules with superior fluidity and low moisture absorption are ideal for tableting and capsule filling. Melt granulation as a solvent-free technology has attracted increasing interest for the granulation of moisture-sensitive drugs. The objective of the present study was to develop a…
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This thesis has focused on the study of pharmaceutical cocrystal production, and the impact of introducing an excipient into the manufacturing process. Cocrystals of sulfadimidine (SDM) and 4-aminosalicylic acid (4ASA) were formed in the presence of an excipient by spray drying and spray coating,…
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