Topical Excipient

See the poster presented by Seppic at DDF Summit in Berlin in June 2023: Introduction Novel topical drug development will require multiple formulation adjustments from the initial formulation studies to the registration phase . Common issues encountered are API chemical instability, API lack…
Read More...

介绍与target-oriented drug discovery and an increasing focus on specialized medicines, the manufacturing of final drug products is becoming more and more complex. The processing and formulation of active pharmaceutical ingredients (APIs) designed with a specific target and functionality…
Read More...

Background & Introduction Excipients play a crucial role in efficacy, safety and quality of medicinal products. In topical dermatological formulations, often complex excipients of natural or semi-synthetic origin with broad specifications are used (1). In parenteral drug delivery, non-ionic…
Read More...

Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are used to deliver different kinds of therapeutics (e.g., small molecules,…
Read More...

Abstract The industry has been paying more attention to the quality of excipients since they play a fundamental role in the efficacy, safety, and acceptability of pharmaceutical products. However, in the case of topical products synthetic compounds have been a concern for consumers, since they can…
Read More...

Topical administration of anti-cancer drugs along with photodynamically active molecules is a non-invasive approach, which stands to be a promising modality for treating aggressive cutaneous melanomas with the added advantage of high patient compliance. However, the efficiency of delivering drugs…
Read More...

Cutaneous drug concentration quantification after topical application remains an active, yet challenging research area for topical drug development. Macroscale approaches quantify cutaneous pharmacokinetics 30 minutes to hours after application and miss rapid temporal and spatial dynamics, vital to…
Read More...

Abstract Objective DCN is a chondro-protective agent which displays inadequate oral bioavailability along with gastrointestinal side effects. It is a choice of drug for treatment of osteoarthritis. Therefore, the objective of this study was to develop and optimize DCN loaded nanostructured lipid…
Read More...

The emulsion-based topical semisolid dosage forms present a high degree of complexity due to their microstructures which is apparent from their compositions comprising at least two immiscible liquid phases, often times of high viscosity. These complex microstructures are thermodynamically unstable,…
Read More...

Chronic wounds affect millions of people globally. This number is set to rise with the increasing incidence of antimicrobial-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA), which impair the healing of chronic wounds. Lacticin 3147 is a two-peptide chain…
Read More...